Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 71(3): 245-253 (2022)


エピガロカテキンガレートおよびエピカテキンによる細胞ならびにDNAの放射線防護効果に関する研究Radiation Protection of Yeast Cells and DNA by Epigallocatechin Gallate and Epicatechin

1ベトナム電力大学Electric Power University, Vietnam

2インドネシア原子力規制庁Nuclear Energy Regulatory Agency (BAPETEN), Indonesia

3福井大学学術研究院工学系部門原子力安全工学講座Department of Nuclear Power and Safety Engineering, University of Fukui, Japan

4福井大学附属国際原子力工学研究所Research Institute of Nuclear Engineering, University of Fukui, Japan

5若狭湾エネルギー研究センターThe Wakasa Wan Energy Research Center, Japan

受付日:2021年10月14日Received: October 14, 2021
受理日:2022年7月28日Accepted: July 28, 2022
発行日:2022年11月15日Published: November 15, 2022


Exposure to ionizing radiation results in the generation of reactive intermediate species such as cation radicals, anion radicals, and free radicals that can induce DNA damage. Epigallocatechin gallate (EGCG) and epicatechin (EC) are natural radiation-protective agents. The radiation protection effects of EGCG and EC against γ-ray and helium ion irradiation were studied using plasmid pUC118 and wild-type yeast. The percentage of strand breaks of pUC118 in the presence or absence of EGCG or EC were evaluated by agarose gel electrophoresis, and the protective effects of EGCG in yeast cells exposed to radiation were assessed by the survival ratio. The percentage of non-damaged plasmid DNA after irradiation increased in the presence of both EGCG and EC, indicating that these compounds can reduce DNA damage induced by γ-ray and helium ion irradiation. Our results show that EGCG and EC may provide effective protection against the harmful effects of ionizing radiation.

Key words: radiation; scavenger; epigallocatechin-gallate; epicatechin; LET; DNA; single-strand break

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