重粒子線治療は，線量の集中性が高く細胞致死効果の高い重粒子線を病巣に集中的に照射する効果的な治療法である。しかし，重粒子線に対するほとんどの物質の線量応答は線エネルギー付与（LET）を通して重粒子線のエネルギーに依存するため，その線量分布を正確に計測することは困難であった。本稿では，高LET放射線の分布を数Gy単位で定量，サブミリメートルの分解能で評価でき，その線量応答がLETに依存しない化学線量計を紹介する。
Heavy ion beam radiotherapy has superior therapeutic benefits because of its higher relative biological effectiveness and reduced oxygen enhancement ratio compared with low LET radiation. However, the precise measurement of dose distributions when using high LET radiation remains a challenge. In this paper, my research group introduces a chemical dosimeter that can evaluate the distribution of high LET radiation with a sub millimeter resolution, within several Gy and without sensitivity correction based on the LET.
Key words: heavy ion beam; 3D gel dosimetry; fluorescence probe; particle therapy; linear energy transfer (LET) effect
© Japan Radioisotope Association 2024. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/)© Japan Radioisotope Association 2024. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/)
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