核医学診断は，適切な診断用核種を導入した放射性薬剤を用いる画像診断法であり，様々な疾患の経時的な診断や病態発現の機構解明が可能となる。また，治療用核種を導入した放射性薬剤は，全身の病巣に対して強い細胞殺傷効果を有するため，新しいがん医療として期待される。本稿では，がんや脳疾患領域における核医学診断や核医学治療のための放射性薬剤開発に関して，著者らの研究を含めた最近の研究動向について概説する。
Nuclear medicine diagnosis is an in vivo imaging technique that employs radiopharmaceuticals in which diagnostic radionuclides are introduced. This technique facilitates the chronological diagnosis of various diseases and elucidates the pathological mechanisms. Radiopharmaceuticals featuring therapeutic radionuclides are anticipated to surve as a novel cancer therapy due to their potent cytotoxic effects on lesions throughout the body. This review focuses on recent research trends in the development of radiopharmaceuticals for nuclear medicine diagnosis and therapy for cancer and brain diseases, including our studies.
Key words: nuclear medicine diagnosis; radionuclide therapy; radiopharmaceuticals; radiotheranostics
© Japan Radioisotope Association 2024. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/)© Japan Radioisotope Association 2024. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/)
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