Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 71(1): 35-40 (2022)


マウス精巣器官培養法を活用した放射線不妊メカニズムの解析Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio-Therapy-Related Male Infertility

1量子科学技術研究開発機構量子生命科学研究所Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology

2茨城大学大学院理工学研究科Graduate School of Science and Technology, Ibaraki University

3北海道大学環境健康科学研究教育センターCenter for Environmental and Health Sciences, Hokkaido University

受付日:2021年9月28日Received: September 28, 2021
受理日:2021年11月16日Accepted: November 16, 2021
発行日:2022年3月15日Published: March 15, 2022


Fertility preservation in radiotherapy is of significance for the quality of life among post-treatment cancer survivors. In this study, using a mouse testicular tissue culture and a common X-ray irradiator, we analyzed the recovery process of spermatogenesis in spatially fractionated radiation fields, suggesting that spermatogonial stem cell migration may be involved in the recovery process. These tissue culture approaches are expected to provide a novel insight into the mechanisms of radiotherapy-related male infertility.

Key words: radiotherapy; male infertility; spermatogenesis; organ culture; time lapse imaging

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