Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 70(4): 279-289 (2021)

総説Review Article

FLASH RadiotherapyFLASH Radiotherapy

1名古屋市立大学医学部附属西部医療センター陽子線治療科Department of Radiation Oncology, Nagoya Proton Therapy Center, Nagoya City University West Medical Center

2名古屋市立大学大学院医学研究科放射線医学分野Department of Radiology, Nagoya City University Graduate School of Medical Sciences

発行日:2021年7月15日Published: July 15, 2021

FLASH Radiotherapyは超高線量率照射のことであり,「障害が軽減される特性」を有している。そのため,放射線治療の今までの概念を覆すものであり,臨床応用ができれば,放射線治療分野でパラダイムシフトとなる潜在的可能性を秘めている。本総説では,背景,生物学的内容,メカニズムや臨床応用へ向けた取り組みなどについて紹介する。

FLASH Radiotherapy is an ultra-high dose rate irradiation, and has a characteristic of reducing the normal tissue damage. Therefore, it overturns the conventional concept of radiotherapy, and if it can be applied clinically, it has the potential to produce a paradigm shift in the field of radiotherapy. In this review, we introduce the background, biological aspects, mechanism, and efforts for clinical application.

Key words: ultra-high dose rate irradiation; conventional dose rate irradiation; normal tissue damage; oxygen depletion; proton therapy

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