Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 70(4): 271-277 (2021)


2光子放出核種のためのコリメータ搭載型コインシデンスイメージングCollimator-based Coincidence Imaging for Double Photon Emitting Nuclides

1東京大学大学院工学系研究科バイオエンジニアリング専攻Department of Bioengineering, The University of Tokyo

2東京大学大学院工学系研究科原子力国際専攻Department of Nuclear Engineering and Management, The University of Tokyo

3東京大学大学院工学系研究科総合研究機構The Institute of Engineering Innovation, The University of Tokyo

受付日:2020年7月24日Received: July 24, 2020
受理日:2021年2月4日Accepted: February 4, 2021
発行日:2021年7月15日Published: July 15, 2021

指向性を持つガンマカメラを用い,光子の時間・位置の相関情報を取得する新しい断層撮像法を提案する。体内の薬剤集積情報を得る際,二光子の時間・位置情報を利用することで高い分解能とSNR(Signal-to-Noise Ratio)が実現可能である。111Inはカスケードγ線を放出する核種として知られる。111Inに加え,本手法に適用可能な核種に関して考察する。本手法では,鉛フォーカシングコリメータとピクセル型検出器を組み合わせ,二光子の同時計測を行う。

We have proposed a new concept of time/position correlation type tomographic method based on a directionality-sensitive gamma camera, which can identify incident γ-ray direction. This method utilizes the correlation between two γ-ray photons and provides the radioactivity concentration in the body with a high resolution and a high signal-to-noise ratio. 111In is known as a cascade γ-ray emitting nuclide. Besides 111In, we have explored new candidates and found some other nuclides with different lifetimes. A focused lead collimator was designed and coupled to a pixelated detector array for this new coincidence imaging modality. The method shows a significant background rejection and an improved spatial resolution in comparison with the single-photon analysis.

Key words: Double-Photon Emission Computed Tomography; coincidence detection; multi-nuclide imaging

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