Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 69(2): 45-53 (2020)


マウス脳における低線量照射による抗酸化機能の亢進とアスコルビン酸投与併用による複合効果の基礎的検討Basic Study on Enhancement of Antioxidant Function by Low-dose Irradiation in Mouse Brain and Its Combined Effect with Ascorbic Acid

岡山大学大学院保健学研究科Graduate School of Health Sciences, Okayama University


元 岡山大学大学院保健学研究科Last position, Graduate School of Health Sciences, Okayama University

受付日:2019年5月31日Received: May 31, 2019
受理日:2019年10月1日Accepted: October 1, 2019
発行日:2020年2月15日Published: February 15, 2020

本研究では,マウス脳における低線量X線(0.1~2.0 Gy)照射の4時間~7日後の抗酸化機能の変化特性,および抗酸化物質であるアスコルビン酸(500 mg/kg体重)の投与併用による複合効果に関して検討した。その結果,低線量照射により概ね過酸化脂質量の減少とSOD活性・HSP量の増加が示された。また,0.5 Gy照射とアスコルビン酸投与の併用により過酸化脂質量の有意な減少が示されたことから,抗酸化の複合効果も示唆できた。

We studied on the characteristics of changes in antioxidant function of mice brains at 4 h to 7 days after low-dose X-ray (0.1 to 2.0 Gy) irradiation, and the combination effect of this and administration of ascorbic acid (500 mg/kg body weight), an antioxidant enzyme. As a result, low-dose irradiation mostly showed decrease in lipid peroxide levels, increase in superoxide dismutase (SOD) activities and heat shock protein (HSP) levels. In addition, the combined use of 0.5 Gy irradiation with ascorbic acid administration showed a significant decrease in lipid peroxide level, suggesting the combined effect of antioxidant.

Key words: low-dose X-ray; ascorbic acid; mouse brain; lipid peroxide level; superoxide dismutase (SOD) activity; heat shock protein (HSP) level

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