Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 68(10): 741-748 (2019)

特集Special Issues

8.2.8 炭素線による発がん8.2.8 Effect of carbon ions on carcinogenesis

量子科学技術研究開発機構放射線医学総合研究所放射線影響研究部Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology ◇ 263–8555 千葉県千葉市稲毛区穴川4–9–1 ◇ 4–9–1 Anagawa, Inage-ku, Chiba 263–8555, Japan

発行日:2019年10月15日Published: October 15, 2019


Heavy ion radiotherapy is expected to reduce the risk of second cancer by decreasing exposure of normal tissues to radiation. Emerging studies have attempted to predict the risk of second cancer after carbon ion radiotherapy based on dose assessment, the epidemiologically-identified risk of photon radiation, and assumptions about the relative biological effectiveness (RBE) of carbon ions. Nevertheless, large uncertainty remains in the choice of RBE of carbon ions in inducing cancer. The present article summarizes carcinogenesis experiments performed in animals using HIMAC. These animal experiments have yielded RBE values for selected tissues, beam types, and age at the time of irradiation. The results indicate potentially variable RBE which depends on tissues, ages, and dose levels. A few additional studies have attempted to identify molecular alterations in tumors induced by carbon ions. Thus, more comprehensive animal carcinogenesis studies are needed.

Key words: HIMAC (Heavy Ion Medical Accelerator in Chiba); carcinogenesis; second cancer; relative biological effectiveness

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