RADIOISOTOPES

Online ISSN: 1884-4111 Print ISSN: 0033-8303
RADIOISOTOPESは日本アイソトープ協会が発行する学術論文誌です
Radioisotopes 68(10): 731-740 (2019)
doi:10.3769/radioisotopes.68.731

特集Special Issues

8.2.7 放射線治療の目線から見たがん転移高LET粒子線によるがん転移の抑制8.2.7 Metastasis of Cancer from the viewpoint of radiation therapyAnti-Metastatic Effects of High LET Particle Beam

1筑波大学医学医療系臨床医学域放射線腫瘍学Radiation Oncology, Clinical Medicine, Faculty of Medicine, University of Tsukuba ◇ 305–8575 茨城県つくば市天王台1–1–1 ◇ 1–1–1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan

2筑波大学附属病院陽子線医学利用研究センターProton Medical Research Center, University of Tsukuba Hospital ◇ 305–8576 茨城県つくば市天久保2–1–1 ◇ 2–1–1 Amakubo, Tsukuba, Ibaraki 305–8576, Japan

発行日:2019年10月15日Published: October 15, 2019
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がんは日本人の2人に1人が罹患し,転移と呼ばれる特異的な性質が様々ながん治療の予後を決定する極めて重要な因子となっている。これは放射線治療においても例外ではないが,粒子線とがんの転移に関する研究は少ない。放医研のHIMACは様々な粒子種及び線質を用いた実験が可能であり,これまでの放射線の「量」による転移影響に加え,「質」の違いによる影響も含めた有用なデータを取得することができた。

One in two people has suffered from cancer in Japan. Cancer has a specific property, called metastasis. Metastasis and recurrence are extremely important factors that determine the prognosis of various cancer treatments. Recent advances in the field of radiotherapy have considerably improved the treatment outcome of various types of cancer based on the benefits of advances in oncology, physics, engineering, biology etc. Although the number of cancer patients receiving radiotherapy is increasing, knowledge about radiation effects on metastasis is not sufficient and radiotherapy targeting metastasis is extremely undeveloped. Experiments using various particle ion species and linear energy transfer are possible with HIMAC of NIRS. By using this facility, it is possible to examine the influence of not only “quantity” but also “quality” of radiation, and to obtain useful data that can contribute to radiation cancer metastasis research.

Key words: HIMAC (Heavy Ion Medical Accelerator in Chiba); cancer; metastasis; radiotherapy; particle therapy; linear energy transfer (LET); immunotherapy

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This page was last modified on 2019-10-07T16:13:22.000+09:00


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