Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 68(10): 681-691 (2019)

特集Special Issues

8.2.1 炭素イオン線による水相における活性酸素種の生成8.2.1 Generation of Reactive Oxygen Species in Aqueous Phase by Carbon-Ion Beam

量子科学技術研究開発機構放射線医学総合研究所放射線障害治療研究部障害分子機構解析研究チームQuantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology ◇ 263–8555 千葉県千葉市稲毛区穴川4–9–1 ◇ 4–9–1 Anagawa, Inage-ku, Chiba, Chiba 263–8555, Japan

発行日:2019年10月15日Published: October 15, 2019


Hydroxyl radical (·OH) generation, hydrogen peroxide (H2O2) generation, and the total amount of oxidation reactions caused by X-ray or carbon-ion beam irradiation to aqueous samples were measured by electron paramagnetic resonance-based methods. The ·OH generation was expected to be localized on the track/range of the carbon-ion beam/X-ray, and millimolar- and molar-levels of ·OH generation were expected. The millimolar-level ·OH generation, H2O2 generation, and total oxidation reaction were suppressed with increasing linear energy transfer (LET). The generation of reactive oxygen species (ROS) was not uniform at the molecular level and was LET dependent. It can be expected that differences in ROS generation and the molecular distribution could make a difference in the quality of radiation therapy.

Key words: HIMAC (Heavy Ion Medical Accelerator in Chiba); reactive oxygen species; carbon-ion beam; electron paramagnetic resonance; electron spin resonance; free radical; redox; oxidative stress; indirect action

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