Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 68(2): 49-58 (2019)

総説Review Article

13C呼気ガステストの精神疾患への応用Application of 13C-based Breath Test in Psychiatric Disorders

1国立精神・神経医療研究センター神経研究所疾病研究第三部Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan ◇ 187–8502 東京都小平市小川東町4–1–1 ◇ 4–1–1 Ogawahigashi, Kodaira, Tokyo 187–8502, Japan

2横浜薬科大学天然物化学研究室・創薬研究センターLaboratory of Natural Products Chemistry, Yokohama University of Pharmacy ◇ 245–0066 神奈川県横浜市戸塚区俣野町601 ◇ 601 Matanocho, Totsuka-ku, Yokohama-shi, Kanagawa Pref. 245–0066, Japan

発行日:2019年2月15日Published: February 15, 2019


We introduced our studies on the possible clinical use of 13C-phynylalanine breath test and 13C-tryptophan breath test in psychiatric disorders. By the phenylalanine test, we detected decreased metabolism of phenylalanine in patients with schizophrenia. In the tryptophan test, on the other hand, we obtained evidence supporting the enhanced metabolism of the tryptophan-kynurenine pathway in patients with major depressive disorder. Collectively, these 13C-labelled breath tests may be useful in the diagnosis and subtyping psychiatric disorders such as schizophrenia and depressive disorder.

Key words: stable isotope; 13C-phynylalanine breath test; 13C-tryptophan breath test; schizophrenia; depressive disorder

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