Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 68(6): 355-359 (2019)

特集Special Issues

4.1 炭素線治療の医学物理4.1 Medical Physics of Carbon Therapy

大阪重粒子線センターOsaka Heavy Ion Therapy Center ◇ 540–0008 大阪府大阪市中央区大手前3–1–10 ◇ 3–1–10 Otemae, Chuo-ku, Osaka City, Osaka 540–0008, Japan

発行日:2019年6月15日Published: June 15, 2019


The change in the radiation quality within a target volume is negligible in low-LET radiation therapy (X-ray therapy, proton-beam therapy), and the therapeutic effect has been predicted empirically based on the absorbed dose. On the other hand, in the case of carbon therapy, which is high-LET, the radiation quality changes markedly within the target volume, especially with the depth. Accompanying this change, the treatment effect (RBE) also changes greatly. Therefore, a new treatment model has been indispensable. We review the beginning of carbon therapy in Japan, and present an introduction to a scanning system, the development of advanced models incorporating the microdosimetry method, and developments concerning various detectors.

Key words: HIMAC(Heavy Ion Medical Accelerator in Chiba); carbon therapy; clinical dose; mixed beam; SOBP(Spread Out Bragg Peak); RBE (Relative Biological Effectiveness)

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