Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 68(4): 239-245 (2019)

特集Special Issues

3.2.2 重粒子照射によるスクロールとL-アラニンラジカルのEPR測定と解析3.2.2 Investigation of Sucrose and L-alanine Radicals Produced by Heavy-ion Irradiation Using EPR

弘前大学大学院保健学研究科Division of Regional Innovation, Graduate School of Health Sciences, Hirosaki University ◇ 036–8564 青森県弘前市本町66–1 ◇ 66–1 Hon-cho, Hirosaki, Aomori 036–8564, Japan

発行日:2019年4月15日Published: April 15, 2019

電子常磁性共鳴(EPR)法を用いてスクロースの重粒子イオンやX線照射で生成するラジカル収量のLET依存性,線量依存性等の測定から,その線量計としての潜在的な適用性をアラニンと比較し検討した。He, C, Si, Neなどの重粒子イオンをスクロースに照射した場合も,X線照射同様,微細構造を有しほぼ7 mTに広がる安定なフリーラジカルの生成が観測された。単位線量あたりラジカル収量は重粒子の照射量の増加に比例して増大するが,LETの増加に対し減少する。同じLETでも軽イオン照射の方が収量は低い。また,2次元EPRイメージングを試みた。空間分解能は0.37 mm程度で,ブラッグピーク領域を検出することができた。

The potential use of a sucrose dosimeter to evaluate linear energy transfer (LET) and absorbed dose measurement for heavy ion and X ray radiation was investigated with electron paramagnetic resonance (EPR) spectroscopy. The observed stable free radicals produced by irradiation with heavy-ions (He, C, Si, Ne ions) and X ray irradiation were similar and exhibit spectra of approximately 7 mT wide with several hyperfine structures. The radical yield produced by ion beam irradiation increased linearly as the absorbed dose increased and decreased logarithmically as the LET increased. In addition, the two-dimensional (2D) EPR imaging with a spatial resolution of ca. 0.37 mm was performed. The high radical intensities in relation to the C ion energy deposition are clearly observed at Bragg peak region.

Key words: HIMAC (Heavy Ion Medical Accelerator in Chiba); sucrose; EPR (Electron Paramagnetic Resonance)

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