Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 67(3): 85-91 (2018)


高感度レーザー分光に基づく生体試料中放射性炭素同位体分析システムの開発Development of Analytical Method for 14C Determination in Biomedical Sample by Laser Spectroscopy

1名古屋大学大学院工学研究科Nagoya University, Graduate School of Engineering ◇ 464–8603 愛知県名古屋市千種区不老町1 ◇ 1 Furo-cho, Chikusa-ku, Nagoya-shi, Aichi Pref. 464–8603, Japan

2積水メディカル株式会社創薬支援センターSekisui Medical Co., Ltd. Drug Development Solutions Center ◇ 319–1182 茨城県那珂郡東海村村松2117 ◇ 2117 Muramatsu, Tokai, Naka-gun, Ibaraki Pref. 319–1182, Japan

受付日:2017年2月28日Received: February 28, 2017
受理日:2017年10月8日Accepted: October 8, 2017
発行日:2018年3月15日Published: March 15, 2018


In recent years, new method called “microdose study” has been developed to directly investigate pharmacokinetics in the human body using a limited amount of 14C labeled candidate compounds which is less than 100 µg or 1% of the dose that yields pharmacological effects. Drug development costs are expected to be dramatically decreased by this new method. Since the required abundance sensitivity of 14C analysis in the microdose studies is 10−10–10−12, Accelerator Mass Spectrometry (AMS) is presently used for this purpose. However, the high cost and limited throughput in 14C analysis by AMS may prevent from wide expansion of the microdose studies to drug development. As an alternative method, we are developing 14C detection system based on Cavity Ring-Down Spectroscopy (CRDS) for microdose studies.

Key words: radiocarbon; microdose study; trace isotope analysis; laser spectroscopy; cavity ring-down spectroscopy

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