Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 67(2): 43-57 (2018)


自己組織化マップを用いた低線量放射線による疾患抑制効果と抗酸化機能亢進に関する特徴抽出Knowledge Discovery of Suppressive Effect of Disease and Increased Anti-oxidative Function by Low-dose Radiation Using Self-organizing Map

1岡山大学大学院保健学研究科Graduate School of Health Sciences, Okayama University ◇ 700–8558 岡山県岡山市北区鹿田町2–5–1 ◇ 5–1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700–8558, Japan

2日本原子力研究開発機構人形峠環境技術センターNingyo-toge Environmental Engineering Center of the Japan Atomic Energy Agency ◇ 708–0698 岡山県苫田郡鏡野町上齋原1550 ◇ 1550 Kamisaibara, Kagamino-cho, Tomata-gun, Okayama 708–0698, Japan

受付日:2017年7月26日Received: July 26, 2017
受理日:2017年9月27日Accepted: September 27, 2017
発行日:2018年2月15日Published: February 15, 2018


We previously reported that low-dose radiation induces the anti-oxidative function in many organ systems of mice. This results in the suppression of several kinds of oxidative stress-induced damage. However, to date, a proven cure has not been established. This study was conducted with the objective of revealing the health effects of low-dose radiation obtained from our previous reports and searching for a new treatment based on low-dose radiation, such as radon therapy. We extracted the characteristics of the effects of low dose radiation suppressing diseases and enhancing the anti-oxidative function using fuzzy answer by self-organizing map (SOM) based on mutual knowledge. The relationship between the suppressive effect and increased anti-oxidative function was shown in our result, and the concentration dependence of the effect against pain was shown on the output map. Although the effect against other organs depending on concentration was unpredictable, our results indicate that low-dose radiation may also be suitable for treatment of liver disease and brain disease. The results presented could encourage development and application of treatment using low-dose radiation, such as radon therapy.

Key words: self-organizing map; low-dose radiation; radon therapy; anti-oxidative function

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