Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 67(7): 309-319 (2018)


リング型乳房専用PET装置の基礎評価と臨床経験The Potential of Dedicated Breast PET with a Ring-type ScannerBasic Evaluation and Clinical Experience

1帝京大学中央RI教育研究施設Department of Radioisotope Research Center, Teikyo university ◇ 173–8605 東京都板橋区加賀2–11–1 ◇ 2–11–1 Kaga, Itabashi-ku, Tokyo 173–8605, Japan

2外苑東クリニックGaien Higashi Clinic PET center ◇ 160–0017 東京都新宿区左門町20番地 ◇ 20 Samoncho, Shinjuku-ku, Tokyo 160–0017, Japan

3国家公務員共済組合連合会東京共済病院乳腺科Department of Breast surgery, Tokyo kyosai Hospital ◇ 153–8934 東京都目黒区中目黒2–3–8 ◇ 2–3–8 Nakameguro, Meguro-ku, Tokyo 153–8934, Japan

4首都大学東京人間健康科学研究科放射線科学域Department of Radiological Sciences, Graduate School of Medicine, Tokyo Metropolitan University ◇ 116–8551 東京都荒川区東尾久7–2–10 ◇ 7–2–10 Higashiogu, Arakawa-ku, Tokyo 116–8551, Japan

5量子科学技術研究開発機構放射線医学総合研究所脳機能イメージング研究部Dept of Functional Brain Imaging Research, National Institute of Radiological Science ◇ 263–8555 千葉県千葉市稲毛区穴川4–9–1 ◇ 4–9–1 Anagawa, Inage-ku, Chiba Pref. 263–8555, Japan

受付日:2017年12月8日Received: December 8, 2017
受理日:2018年3月4日Accepted: March 4, 2018
発行日:2018年7月15日Published: July 15, 2018

本研究の目的は、dedicated breast PET(db-PET)が乳がんの診断に有効であるか調査することである。NEMA NU-4 2008ファントムを使用してdb-PETの画像再構成パラメータを最適化した。75名の乳がん症例において、全身用PET/CT装置によって得られたWB-PET画像とdb-PET画像を比較検討した。


In breast cancer, the survival rate is related to the size of the lesion. Since the spatial resolution of whole-body (WB)-PET is limited, it is difficult to evaluate small cancerous lesions. To improve resolution, high-resolution dedicated breast PET (db-PET) scanners have been developed. However, the potential of db-PET has not yet been established, and there has been no report of the application of db-PET on an Oncovision device (MAMMI) in breast cancer cases in Japan.

The purpose of this study was to evaluate the potential of db-PET for assessing breast cancer. The influence of image reconstruction parameters was verified in a phantom evaluation, while we quantitatively investigated the ability of dB-PET to detect tumors, in comparison with WB-PET, with patients in the prone position, in a clinical evaluation. Despite a limited field of view in the vicinity of the chest wall, we show that db-PET has markedly better clinical value for diagnosing breast cancer as compared to WB-PET.

Key words: positron-emission tomography; 18F-fluorodeoxyglucose; dedicated breast PET; breast cancer; reconstruction parameter

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