RADIOISOTOPES

Online ISSN: 1884-4111 Print ISSN: 0033-8303
RADIOISOTOPESは日本アイソトープ協会が発行する学術論文誌です
Radioisotopes 67(7): 309-319 (2018)
doi:10.3769/radioisotopes.67.309

原著Article

リング型乳房専用PET装置の基礎評価と臨床経験The Potential of Dedicated Breast PET with a Ring-type Scanner—Basic Evaluation and Clinical Experience—

三本 拓也1，宇野 公一2，入江 美幸2，Wu Jin2，笹森 寛人2，土屋 慶宙2，秋葉 雄樹2，中島 玉実2，馬場 紀行3，井上 一雅4，福士 政広4，藤井 智彦1，岸本 成史1，菅野 巖5Takuya Mitsumoto1, Kimiichi Uno2, Miyuki Irie2, Jin Wu2, Hiroto Sasamori2, Yoshimichi Tsuchiya2, Yuki Akiba2, Tamami Nakajima2, Noriyuki Baba3, Kazumasa Inoue4, Masahiro Fukushi4, Norihiko Fujii1, Seishi Kishimoto1, Iwao Kanno5

1 帝京大学中央RI教育研究施設Department of Radioisotope Research Center, Teikyo university ◇ 173–8605　東京都板橋区加賀2–11–1 ◇ 2–11–1 Kaga, Itabashi-ku, Tokyo 173–8605, Japan

2 外苑東クリニックGaien Higashi Clinic PET center ◇ 160–0017　東京都新宿区左門町20番地 ◇ 20 Samoncho, Shinjuku-ku, Tokyo 160–0017, Japan

3 国家公務員共済組合連合会東京共済病院乳腺科Department of Breast surgery, Tokyo kyosai Hospital ◇ 153–8934　東京都目黒区中目黒2–3–8 ◇ 2–3–8 Nakameguro, Meguro-ku, Tokyo 153–8934, Japan

4 首都大学東京人間健康科学研究科放射線科学域Department of Radiological Sciences, Graduate School of Medicine, Tokyo Metropolitan University ◇ 116–8551　東京都荒川区東尾久7–2–10 ◇ 7–2–10 Higashiogu, Arakawa-ku, Tokyo 116–8551, Japan

5 量子科学技術研究開発機構放射線医学総合研究所脳機能イメージング研究部Dept of Functional Brain Imaging Research, National Institute of Radiological Science ◇ 263–8555　千葉県千葉市稲毛区穴川4–9–1 ◇ 4–9–1 Anagawa, Inage-ku, Chiba Pref. 263–8555, Japan

受付日：2017年12月8日Received: December 8, 2017
受理日：2018年3月4日Accepted: March 4, 2018
発行日：2018年7月15日Published: July 15, 2018
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本研究の目的は、dedicated breast PET（db-PET）が乳がんの診断に有効であるか調査することである。NEMA NU-4 2008ファントムを使用してdb-PETの画像再構成パラメータを最適化した。75名の乳がん症例において、全身用PET/CT装置によって得られたWB-PET画像とdb-PET画像を比較検討した。

db-PETの定量性および検出能は、WB-PETと比較して統計学的に有意に改善し、乳がんの診断能向上に有効であることが明らかとなった。

In breast cancer, the survival rate is related to the size of the lesion. Since the spatial resolution of whole-body (WB)-PET is limited, it is difficult to evaluate small cancerous lesions. To improve resolution, high-resolution dedicated breast PET (db-PET) scanners have been developed. However, the potential of db-PET has not yet been established, and there has been no report of the application of db-PET on an Oncovision device (MAMMI) in breast cancer cases in Japan.

The purpose of this study was to evaluate the potential of db-PET for assessing breast cancer. The influence of image reconstruction parameters was verified in a phantom evaluation, while we quantitatively investigated the ability of dB-PET to detect tumors, in comparison with WB-PET, with patients in the prone position, in a clinical evaluation. Despite a limited field of view in the vicinity of the chest wall, we show that db-PET has markedly better clinical value for diagnosing breast cancer as compared to WB-PET.

Key words: positron-emission tomography; 18F-fluorodeoxyglucose; dedicated breast PET; breast cancer; reconstruction parameter

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