Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 66(8): 307-310 (2017)

資料Materials (Data)

全身オートラジオグラフィによる放射性ヨウ素標識コバルト–ブレオマイシンの担がん動物における体内分布の研究The Studies of in Vivo Distributions of Radioiodinated Cobalt-bleomycin in Tumor-bearing Animals by the Whole Body Autoradiography

1岡山大学医学部放射線医学教室Department of Radiology, Okayama University Medical School ◇ 700–8558 岡山県岡山市北区鹿田町2–5–1 ◇ 2–5–1 Shikata-cho, Okayama Pref. 700–8558, Japan

2香川大学総合生命科学研究センター放射性同位元素実験部門(医学部地区)Division of Radioisotope Research, Life Science Research Center, Kagawa University ◇ 761–0793 香川県木田郡三木町池戸1750–1 ◇ 1750–1 Ikenobe, Miki-cho, Kita-gun, Kagawa Pref. 761–0793, Japan

3国際医療福祉大学医学部解剖学Departmemt of Anatomy, School of Medicine, International University of Health and Welfare ◇ 286–8686 千葉県成田市公津の杜4–3 ◇ 4–3 Kozunomori, Narita, Chiba Pref. 286–8686, Japan

4香川大学医学部放射線医学教室Department of Radiology, Faculty of Medicine, Kagawa University ◇ 761–0793 香川県木田郡三木町池戸1750–1 ◇ 1750–1 Ikenobe, Miki-cho, Kita-gun, Kagawa Pref. 761–0793, Japan

5岡山大学大学院保健学研究科Radiological Technology, Graduate School of Health Sciences, Okayama University ◇ 700–8558 岡山県岡山市北区鹿田町2–5–1 ◇ 2–5–1 Shikata-cho, Okayama Pref. 700–8558, Japan

受付日:2016年8月30日Received: August 30, 2016
受理日:2017年3月27日Accepted: March 27, 2017
発行日:2017年8月15日Published: August 15, 2017


High tumor uptake of cobalt-bleomycin suggested that it would be a suitable starting material for chemical modification study. We already described the synthesis of 3-125I-iodobenzyl cobalt-bleomycin and its in vivo distributions in tumor-bearing animals. In the present study, it was shown by the whole body autoradiogram that 3-125I-iodobenzyl cobalt-bleomycin accumulated in tumor (dorsum, thigh, neck), the kidney, the liver and feces. Tumor affinity of this compound was proved by the results of the whole body autoradiogram.

Key words: cobalt-bleomycin; iodine-125; scid mouse; malignant tumor; whole body autoradiography

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