Online ISSN: 1884-4111 Print ISSN: 0033-8303
Radioisotopes 65(6): 257-266 (2016)


小動物用X線CTを用いた矮小ラットの体組成の加齢変化の測定Comparison of Body Composition between Spontaneous Dwarf and Wild-type Rats during Aging—A Quantitative X-ray Computed Tomographic Study

1北里大学医療衛生学部医療工学科診療放射線科学専攻Department of Medical Engineering and Technology, 
Kitasato University School of Allied of Health Sciences ◇ 252–0373 神奈川県相模原市南区北里1–15–1 ◇ 1–15–1 Kitasato, Sagamihara-shi, Kanagawa Pref. 252–0373, Japan

2東京都健康長寿医療センター研究所老化機構研究チームレドックス研究Research Team for Mechanism of Aging, Redox Research, Tokyo Metropolitan Institute of Gerontology ◇ 173–0015 東京都板橋区栄町35–2 ◇ 35–2 Sakae-cho, Itabashi-ku, Tokyo 173–0015, Japan

3芝浦工業大学システム理工学部Department of Bioscience and Engineering, College of Systems Engineering and Science, 
Shibaura Institute of Technology ◇ 337–8570 埼玉県さいたま市見沼区深作307 ◇ 307 Fukasaku, Minuma-ku, Saitama-shi, Saitama Pref. 337–8570, Japan

4東京都健康安全研究センター食品化学部食品添加物研究科Division of Food Additives, Tokyo Metropolitan Institute of Public Health ◇ 169–0073 東京都新宿区百人町3–24–1 ◇ 3–24–1 Hyakunin-cho, Shinjuku-ku, Tokyo 169–0073, Japan

5東京都健康長寿医療センター研究所実験動物施設Animal Center, Tokyo Metropolitan Institute of Gerontology ◇ 173–0015 東京都板橋区栄町35–2 ◇ 35–2 Sakae-cho, Itabashi-ku, Tokyo 173–0015, Japan

6人間総合科学大学人間学部Graduated School of University of Human Arts and Sciences ◇ 339–8539 埼玉県さいたま市岩槻区太田字新正寺曲輪354–3 ◇ 1288 Magome, Iwatsuki-ku, Saitama-shi, Saitama Pref. 339–8539, Japan

受付日:2015年11月22日Received: November 22, 2015
受理日:2016年3月9日Accepted: March 9, 2016
発行日:2016年6月15日Published: June 15, 2016


小型小動物用X線CT装置でラットの皮下と内臓脂肪の加齢変化を弁別して解析することができた。SDRはSDに比べて脂肪肥満傾向を呈した。この肥満は皮下脂肪を主体とし,内臓脂肪にはよらないことがわかった。腹部の脂肪率はSDR, SDのいずれも加齢に伴って増加した。しかし,内臓脂肪の増加率は皮下脂肪に比して顕著であった。

A growth hormone deficiency is associated with increases in body fat. However, it currently remains unclear whether subcutaneous- or/and intra-abdominal adipose tissues are markedly elevated in dwarf obesity. Experiments were conducted on the spontaneous dwarf rats (SDRs) and normal Sprague-Dawley (SD) rats using an X-ray computed tomography scanner to determine body composition. A longitudinal study of aging was also conducted to track age-related changes in body composition using same animals.

We succeeded to estimate the subcutaneous and intra-abdominal adipose tissue mass in rat by X-ray CT. SDRs demonstrated the dwarf obesity, but SDs did not. SDRs developed dwarf obesity due to the accumulation of subcutaneous-abdominal adipose tissue, but not intra-abdominal adipose tissue. Age-dependent increases in the abdominal adipose tissue were observed in both SDRs and SDs. However, age-dependent increases in intra-abdominal adipose tissue were greater than in subcutaneous-abdominal adipose tissue.

Key words: Aging; body fat; growth hormone; spontaneous dwarf rat; X-ray CT

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